Integra doesn't say that she hopes Dean doesn't ever live it, but she thinks it. She knows full well that it's an unfair thought, stubbornly childish at best, but she's seen people - not just Sam - from the future of that world, even without knowing what she does, she wouldn't wish it on anyone. Home may be where people belong, but sometimes...

(It's funny, perhaps, that despite what she thinks about Dean, she really would prefer to be back home, knee-deep in the blood of eight million people.)

Sandwich, then, and she hands it to him (in a paper towel) when she's done. "He does fine work despite it." Senior staff and everything.