The easiest way to go is up; Indira leaps forward, landing somewhere behind the detached skull, and then up again onto a nearby chimney. Apparently that's not enough to kill it. She's not very surprised, at this point, but she's annoyed.

“Any idea how to kill this fucker?” she calls down to Steph. Her own ideas are along the lines of pulverize it but this thing is huge and if its bits can function separately, there probably isn't time for her to grind it down into bonedust without something else trying to step on her.